Strategies for the control of geminivirus diseases |
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| Institution: | 1. Department of Molecular Life Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan;2. Micro/Nano Technology Center, Tokai University, 411 Kitakaname, Hiratsuka, Kanagawa 259-1292, Japan;1. Department of Plant Protection, College of Agriculture, Shahid Bahonar University of Kerman, Kerman 7616914111, Iran;2. Research and Technology Institute of Plant Production (RTIPP), Shahid Bahonar University of Kerman, 7616914111, Iran;3. The Biodesign Center of Fundamental and Applied Microbiomics, School of Life Sciences, Center for Evolution and Medicine, Arizona State University, 1001 S. McAllister Ave, Tempe, AZ 85287-5001, USA;4. Structural Biology Research Unit, Department of Integrative Biomedical Sciences, University of Cape Town, Observatory, Cape Town, South Africa |
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| Abstract: | Geminiviruses are unique plant DNA viruses that frequently cause significant yield reductions in a wide range of cereal, vegetable and fibre crops. Encouraging progress has recently been made towards the control of geminiviruses that infect dicotyledonous plants. Under laboratory conditions, defective interfering (DI) DNA and antisense strategies, both directed against viral DNA replication, have been used to protect Nicotiana spp. against the bipartite geminivirus African cassava mosaic virus and tomato golden mosaic virus. The use of dominant negative mutants of virus systemic movement might also be adapted as a novel strategy for the control of these important pathogens. |
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