Fiber type composition and enzyme activities of muscles in two models of obese rats |
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| Institution: | 1. Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research-Raebareli, Lucknow, India;2. ICMR-National Institute of Occupational Health, Ahmedabad, India;3. Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India;1. Department of Statistics, College of Natural and Computational Science, Debre Tabor University, Debre Tabor, Ethiopia;2. Department of Statistics, College of Science, Bahir Dar University, Bahir Dar, Ethiopia |
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| Abstract: | - 1.1. In oxidative (soleus) and glycolytic (extensor digitorum longus) muscles of obese Zucker rats, a significant decrease in the percentage of relative area occupied by glycolytic fibers was observed.
- 2.2. The activity of citrate synthase and β-hydroxy-acyl-CoA-dehydrogenase was significantly higher in muscles of obese than of lean Zucker rats.
- 3.3. In rats, 6 weeks after lesion of the ventromedial hypothalamus, no changes were observed.
- 4.4. This indicates that neither the proportion of oxidative fibers, nor the oxidative capacities are decreased in skeletal muscles of obese rats suggesting that insulin resistance cannot be ascribed to a higher glycolytic-oxidative fiber ratio.
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