The molecular biology of hepatitis C virus |
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| Institution: | 1. Institut de Recherches Cliniques de Montréal (IRCM), Montreal, QC, Canada;2. Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada;3. Department of Anatomy and Cell Biology, Department of Biology, McGill University, Montreal, QC, Canada;4. Department of Medicine, University of Montreal, Montreal, QC, Canada;5. Division of Experimental Medicine, McGill University, Montreal, QC, Canada |
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| Abstract: | Hepatitis C virus (HCV) is one of the main causative agents for transfusion associated- and sporadic cases of non-A, non-B hepatitis throughout the world. HCV has a positive strand RNA of about 9400 nucleotides, as its genome, whose organization is similar to those of animal pestiviruses or human flaviviruses. In spite of the lack of the effective replication system in tissue culture cells, parts of the viral genome were expressed under the control of foreign promoters and the synthesized viral protein has been used for diagnostic assays. |
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