The effect of MS-222 on paced ventricle strips and the perfused heart of rainbow trout,Oncorhyncus mykiss |
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| Institution: | 3. Institute for Global Food Security, Queen''s University, Belfast, United Kingdom;1. Fundação Instituto de Pesca do Estado do Rio de Janeiro – Fiperj, Departamento de Pesquisa e Produção, Praça Fonseca Ramos s/n°, Terminal Rodoviário Roberto Silveira, Niterói, RJ, Brazil;2. Programa de Pós-Graduação em Ciência Animal, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Avenida Alberto Lamego, n° 2.000, Horto, CEP 28015-620 Campos dos Goytacazes, RJ, Brazil |
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| Abstract: | 1. The contractile force of trout ventricle strips fell in a dose-dependent manner with increasing concentrations of MS-222.2. Ventricle strips immersed in a superfusate containing 27 mg l−1 MS-222 had an equivalent concentration in the tissue. At 54 mg l−1 the tissue concentration was significantly lower than the superfusate.3. A concentration of 10 mg l−1 MS-222 in the perfusate produced a 25% drop in force of contraction of ventricle strips.4. Isolated perfused hearts pumping perfusate with 10 mg l−1 MS-222 also showed a fall of approximately 25% in maximum cardiac output and maximum power output.5. Tissue anaesthetic levels in the ventricles of superfused trout hearts were found to be three-fold higher than that in the perfusate.6. The need for caution when using MS-222 in physiological experiments is therefore emphasized. |
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