Entry of alphaherpesviruses into cells |
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| Affiliation: | 1. Helmholtz-Zentrum Dresden-Rossendorf, Institute of Fluid Dynamics, Bautzner Landstr. 400, 01328 Dresden, Germany;2. Chair of Chemical Reaction Engineering and Process Plants, Institute of Process Engineering and Environmental Technology, Technische Universität Dresden, 01062 Dresden, Germany;3. AREVA Endowed Chair of Imaging Techniques in Energy and Process Engineering, Technische Universität Dresden, 01062 Dresden, Germany |
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| Abstract: | Studies on four alphaherpesviruses (herpes simplex virus types 1 and 2, pseudorabies virus and bovine herpesvirus 1) have revealed some common features of their entry into cells. The pathway of entry can be by fusion of the virion envelope with the cell plasma membrane. Receptors for binding and entry include heparan sulphate moieties of cell surface proteoglycans and other as yet unidentified cell surface components. Related glycoproteins specified by each of the four viruses mediate the binding of virus to heparan sulphate and subsequent molecular interactions leading to the penetration of virus into the cell. |
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