A comparative study of liver mixed function oxidases in camels (Camelus dromedarius), guinea pigs (Cavia porcellus) and rats (Rattus norvegicus) |
| |
| Institution: | 1. Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand;2. Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand;3. Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand;4. Graduate School, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen 40002, Thailand;5. Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen 40002, Thailand;6. Department of Veterinary Pathobiology, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen 40002, Thailand;7. Department of Microbiology, Immunology & Tropical Medicine, Research Center for Neglected Diseases of Poverty, School of Medicine and Health Sciences, George Washington University, Washington, DC 20037, United States;8. WHO Collaborating Centre for Research and Control of Opisthorchiasis (Southeast Asian liver fluke disease), Khon Kaen University, Khon Kaen 40002, Thailand |
| |
| Abstract: | 1. The activities of the drug-metabolizing enzymes, benzphetamine N-demethylase, 7-ethoxy-coumarin O-deethylase and dicoumarol oxidation have been measured in vitro in the liver of camels, guinea pigs and rats.2. In these species, levels of hepatic microsomal parameters namely microsomal protein, cytochrome P450, cytochrome b5 and NADPH-cytochrome c reductase have also been determined.3. In general, camels seemed to have the lowest enzyme activity when compared to rats and guinea pigs.4. Some sex differences were observed in the levels of enzymes studied. In rats and guinea pigs, males had higher benzphetamine N-demethylase than females. However, in camels and guinea pigs, females had higher 7-ethoxycoumarin O-deethylase when compared to males. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
