In vivo adaptative regulation of muscarinic receptors and muscarinic stimulation-induced Ca2+ mobilization during short-term heat exposure in rat parotid glands期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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In vivo adaptative regulation of muscarinic receptors and muscarinic stimulation-induced Ca2+ mobilization during short-term heat exposure in rat parotid glands

Institution:	1. Department of Pharmacology, Faculty of Medicine, Minia University, 61511 Minia, Egypt;2. Department of Pathology, Faculty of Medicine, Minia University, Minia, Egypt;1. The Peac Institute of Multiscale Sciences, Chengdu, Sichuan 610031, PR China;2. Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, Sichuan 610031, PR China

Abstract:	1. Adaptation of muscarinic receptors (MR)—muscarinic stimulation—induced intracellular Ca²⁺ mobilization during short-heat exposure (33°C).2. Heat-exposure for 48 hr decreased the carbachol (CCh)-stimulated cytosolic C²⁺ concentration increase.3. The number of MR on cell surface increased transiently at 24 hr with a subsequent decrease at 48 hr.4. CCh-stimulated inositol trisphosphate (IP₃) formation decreased at 48 hr.5. In saponin-permeabilized cells, 1,4,5-IP₃-induced ⁴⁵Ca²⁺ release decreased at 24 hr.6. The data suggest that the adaptation for increased muscarinic stimulation occurs at IP₃ generating sites as well as at intracellular IP₃ receptor sites during heat exposure.

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