Insulin-like growth-factor binding protein (IGFBP) serum levels and hepatic IGFBP-2 and -3 mRNA expression in diabetic and insulin-treated swine (Sus scrofa) |
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| Affiliation: | 1. Department of Wildlife Diseases, Leibniz Institute for Zoo and Wildlife Research, Berlin 10315, Germany;2. Department of Biologie, Chemie, and Pharmazie, Freie Universität Berlin, Berlin 14195, Germany;3. Department of Ecological Dynamics, Leibniz Institute for Zoo and Wildlife Research, Berlin 10315, Germany;4. World Wild Fund for Nature, Phnom Penh 120102, Cambodia;5. WWF Germany, Berlin 10117, Germany;6. Department of Evolutionary Genetics, Leibniz Institute for Zoo and Wildlife Research, 10315 Berlin, Germany;7. Ministry of Environment, Phnom Penh 120101, Cambodia;8. School of Veterinary Medicine, Freie Universität Berlin, Berlin 14163, Germany |
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| Abstract: | - 1.1. Diabetes had no significant effect on IGFBP-3 message and serum levels however, subsequent insulin treatment caused more than a two-fold increase in both hepatic IGFBP-3 mRNA and serum levels above controls (P < 0.05).
- 2.2. The induction of diabetes in pigs significantly increased the steady state levels of IGFBP-2 mRNA in the liver of young swine (P < 0.05).
- 3.3. Both liver message and serum IGFBP-2 were reduced to control levels with insulin therapy.
- 4.4. We report here that in addition to its affects on IGFBP-2, insulin is involved in the regulation of IGFBP-3 expression.
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