Dendrimers in gene transfection |
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| Authors: | D. G. Shcharbin B. Klajnert M. Bryszewska |
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| Affiliation: | (1) Department of Biomedical Engineering, Virginia Commonwealth University, 701 West Grace Street, Laurel Street Entrance, P.O. Box 843067, Richmond, VA 23284-3067, USA;(2) Department of Chemical and Biomolecular Engineering, The University of Akron, Akron, OH 44325, USA;(3) Department of Biomedical Engineering, The University of Akron, Akron, OH 44325, USA;(4) Falor Division of Surgical Research, Akron City Hospital, Summa Health System, Akron, OH 44309, USA |
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| Abstract: | Dendrimers are a new class of nanocomposite materials. They are branching polymers whose structure is formed by monomeric subunit branches diverging to all sides from a central nucleus. The type of nucleus, attached monomers, and functional groups can be chosen during synthesis, which produces dendrimers of definite size, shape, density, polarity, branch mobility, and solubility. This review deals with problems of dendrimer molecular structures and capability of in vitro, in vivo, ex vivo, and in situ transfection of genetic material. Advantages and shortcomings of different types of dendrimers in this respect are discussed. |
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