| 功能矫形前伸青春期大鼠下颌后翼外肌MyoD、myogenin 的表达 |
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| 引用本文： | 达雨,杨竹丽,袁晓,杜衍晓,田臻,王梦佳.功能矫形前伸青春期大鼠下颌后翼外肌MyoD、myogenin 的表达[J].现代生物医学进展,2011,11(6):1020-1024. |
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| 作者姓名： | 达雨 杨竹丽 袁晓 杜衍晓 田臻 王梦佳 |
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| 作者单位： | 1. 青岛大学医学院,山东,青岛,266021
2. 青岛市市立医院口腔科,山东,青岛,266071 |
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| 基金项目： | 国家自然科学基金资助项目，青岛市科技局科技支撑计划 |
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| 摘 要： | 目的:探讨"应力-生长(改建)"在细胞水平上的体现,为功能矫形治疗和矫治效果的保持提供新思路和实验依据。方法:本实验选用20只4周龄,雄性SD大鼠随机分为8组。其中实验组大鼠经戊巴比妥麻醉后佩戴上颌斜面导板,对照组未佩用。依据时间不同又分为四组:1d,7d,14d,21d。采用RT-PCR技术分析各组大鼠翼外肌组织中肌分化相关基因MyoD、myogenin mRNA的表达变化。结果:未施加功能矫形力的大鼠翼外肌组织MyoD表达伴随其生长发育呈现递减趋势,实验组在第7 d出现表达上调。同时,力学刺激后实验组动物myogenin的表达与对照组相比较在14 d组出现明显上调。结论:功能矫形力作用于翼外肌组织可以诱导MyoD和myogenin的表达上调进而诱导成肌细胞的分化。
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| 关 键 词： | 应力介导 成肌细胞 分化 成肌调节因子 翼外肌 |
Expression of MyoD, Myogenin mRNA in Juvenile Rats Lateral
Pterygoid after Functional Mandibular Protrusion |
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| DA Yu,YANG Zhu-li,YUAN Xiao,DU Yan-xiao,TIAN Zhen,WANG Meng-jia.Expression of MyoD, Myogenin mRNA in Juvenile Rats Lateral
Pterygoid after Functional Mandibular Protrusion[J].Progress in Modern Biomedicine,2011,11(6):1020-1024. |
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| Authors: | DA Yu YANG Zhu-li YUAN Xiao DU Yan-xiao TIAN Zhen WANG Meng-jia |
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| Institution: | DA Yu1,YANG Zhu-li2,YUAN Xiao2,DU Yan-xiao1,TIAN Zhen1,WANG Meng-jia1(1 Affiliated Hospital of Qingdao University Medical College,Qingdao Municipal Hospital,Qingdao Shandong266021,China,2 Department of Stomatology,Qingdao Shandong 266071,China) |
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| Abstract: | Objective:To investigate the expression of stress-growth(reconstruction) at the cellular level for provide new ideas and experimental evidence about functional orthopedic treatment and treatment effects remain.Methods:Twenty,28 days old,male Sprague-Dawley(SD) rats were chosen in this research.SD rats are randomly divided into eight groups:control 1 d,7 d,14 d,21 d and experimental 1 d,7 d,14 d,21 d.When rats were anaesthetized by intraperitoneal injections of pentobarbital,the inclined bite plate were put... |
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| Keywords: | Stress-induced Myoblast Differentiation MRFs Lateral pterygoid |
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