Secondary metabolites and cytotoxic activities from the endophytic fungus Annulohypoxylon squamulosum |
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| Authors: | Ming-Jen Cheng Ming-Der Wu Gwo-Fang Yuan Yen-Lin Chen Yung-Shun Su Ming-Tsuen Hsieh Ih-Sheng Chen |
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| Affiliation: | 1. Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan;2. Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan;3. School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan;4. School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan |
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| Abstract: | One new dihydrobenzofuran-2,4-dione derivative, designated as annulosquamulin (1), together with 10 known compounds (2–11), were isolated from the n-BuOH-soluble fraction of the 95% EtOH extract of long-grain rice fermented with the endophytic fungus Annulohypoxylon squamulosum BCRC 34022, derived from the stem bark of medicinal plant Cinnamomum sp. Annulosquamulin (1) comprises one dihydrobenzofuran-2,4-dione skeleton, 1-hydroxydecyl side chain, and one γ-lactone ring. Their structures were elucidated by means of spectroscopic and mass-spectrometric analyses, particularly 1D and 2D NMR spectroscopy as well as HRESIMS. All known isolates except 11, were isolated for the first time from this species. In addition, isolated compounds (1–5) were evaluated for their cytotoxicity against the MCF-7, NCI-H460 and SF-268 cell lines using the MTT assay. |
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