Eurocristatine,a new diketopiperazine dimer from the marine sponge-associated fungus Eurotium cristatum |
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| Authors: | Nelson M. Gomes Tida Dethoup Narong Singburaudom Luís Gales Artur M.S. Silva Anake Kijjoa |
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| Affiliation: | 1. ICBAS - Instituto de Ciências Biomédicas de Abel Salazar and CIIMAR, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal;2. Department of Plant Pathology, Faculty of Agriculture, Kasetsart University, Bangkok, Thailand;3. ICBAS - Instituto de Ciências Biomédicas de Abel Salazar and Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal;4. Departamento de Química, Universidade de Aveiro, 4810-1933 Aveiro, Portugal |
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| Abstract: | A new diketopiperazine dimer, eurocristatine (1), was isolated, in addition to eight known metabolites including the anthraquinones erythroglaucin, physcion, catenarin, emodin and the dioxopiperazine alkaloids echinulin, neoechinulin A, neoechinulin E, variecolorin J, from the culture of the sponge-associated fungus Eurotium cristatum KUFC 7356. The structure of eurocristatine (1) was established based on 1D and 2D NMR spectral analysis as well as HRESIMS, and the absolute configuration of its stereogenic carbons was determined by an X-ray crystallographic analysis. Eurocristatine (1) did not exhibit cytotoxic, antibacterial or antifungal activity. |
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