Stigmastane derivatives from the roots of Vernonia guineensis and their antimicrobial activity |
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| Authors: | Arno R.N. Donfack Ngeh J. Toyang Hippolyte K. Wabo Pierre Tane Maurice D. Awouafack Haruhisa Kikuchi Jean D.D. Tamokou Jules R. Kuiate Yoshiteru Oshima |
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| Affiliation: | 1. Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon;2. Institute of Human Virology, University of Maryland School of Medicine, USA;3. Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan;4. Department of Biochemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon |
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| Abstract: | Chemical investigation of the roots of Vernonia guineensis (Asteraceae) afforded a new stigmastane derivative, vernoguinoside A (1) and the known vernoguinoside (2), stigmasterol 3-O-β-d-glucoside (3) and sitosterol 3-O-β-d-glucoside (4). Their structures were elucidated by spectroscopic analysis. Antimicrobial activities of 1–3 and CH2Cl2–MeOH (1:1) extract were evaluated against three bacteria species (Salmonella typhi, Staphylococcus aureus and Shigella flexneri) and three yeasts species (Candida albicans, Candida parapsilosis and Cryptococcus neoformans). Compounds 1 and 2 exhibited both antibacterial and antifungal activities that varied between the microbial species (MIC = 7.81–125 μg/mL) while S. flexneri and C. albicans were sensitive to all the tested compounds. |
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