A new cytotoxic apotirucallane from the roots of Walsura trichostemon |
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| Authors: | Jirapast Sichaem Thammarat Aree Suttira Khumkratok Jonkolnee Jong-aramruang Santi Tip-pyang |
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| Institution: | 1. Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand;2. Walai Rukhavej Botanical Research Institute, Mahasarakham University, Mahasarakham 44000, Thailand;3. Department of Chemistry, Faculty of Science, Burapha University, Chonburi 20231, Thailand;4. Center for Petroleum, Petrochemicals and Advanced Materials, Chulalongkorn University, Bangkok 10330, Thailand |
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| Abstract: | A new apotirucallane, trichostemonate (1), was isolated from the roots of Walsura trichostemon. The complete structural assignment of this new compound was elucidated from spectroscopic methods and the stereochemistry of 1 was confirmed by X-ray crystallographic analysis. Moreover, this new compound was evaluated for its cytotoxicity (KB and HeLa cells), and showed significant cytotoxicity against both KB and HeLa cell lines with IC50 values of 3.28 and 0.93 μg/mL, respectively. |
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