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Bioactive styryllactones,two new naphthoquinones and one new styryllactone,and other constituents from Goniothalamus scortechinii
Authors:Uma Prawat  Sawitree Chaimanee  Akkarapol Butsuri  Abdul-Wahab Salae  Pittaya Tuntiwachwuttikul
Institution:Laboratory of Natural Products Chemistry, Faculty of Science and Technology, Phuket Rajabhat University, Muang, Phuket 83000, Thailand
Abstract:Two new naphthoquinones, goniothalaminone A (1) and B (2), and a new styryllactone, (?)-8-epi-9-deoxygoniopypyrone acetate (12) together with one known naphthoquinone (3), one known indolequinone (4), one known 1-azaanthraquinone (5), six known styryllactones (611) and one known sesquiterpene (13) were isolated from the roots and leaves of Goniothalamus scortechinii. The structures of the new compounds were elucidated by spectroscopic analysis and of the known compounds by comparison of their physical, UV, IR, 1H and 13C NMR data with those of published compounds. Antiplasmodial, antimycobacterial and cytotoxic activities of the styryllactones were evaluated. Compounds 610 exhibited cytotoxic against human cancer cell lines, KB, BC and NCI-H187 with IC50 values ranging from 0.13 to 11.7 μg/ml.
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