ABO blood group and risk of renal cell cancer |
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| Authors: | Hee-Kyung Joh Eunyoung Cho Toni K. Choueiri |
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| Affiliation: | 1. Department of Nutrition, Harvard School of Public Health, Boston, MA, USA;2. Department of Global Health and Population, Harvard School of Public Health, Boston, MA, USA;3. Department of Medicine, Seoul National University College of Medicine, Seoul, South Korea;4. Department of Medicine, Brigham and Women''s Hospital, Boston, MA, USA;5. Kidney Cancer Center, Dana-Farber Cancer Institute, Brigham and Women''s Hospital and Harvard Medical School, Boston, MA, USA;1. Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran;2. Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran;3. German Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany;4. Department of Medical Epidemiology& Biostatistics, Karolinska Institute, Stockholm, Sweden;1. University of Leeds Medical School, Leeds, United Kingdom;2. Department of Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island;3. Department of Pediatrics, Warren Alpert Medical School of Brown University, Providence, Rhode Island;4. Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island;1. Nano-Biotechnology Laboratory, II Orthopaedic Clinic, Rizzoli Orthopaedic Institute, Via di Barbiano 1/10, 40136 Bologna, Italy;2. Biomechanics Laboratory, II Orthopaedic Clinic, Rizzoli Orthopaedic Institute, Via di Barbiano 1/10, 40136 Bologna, Italy |
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| Abstract: | Background: The genetic determinants of sporadic renal cell cancer (RCC) are largely unknown. Previous studies have suggested associations between ABO blood group and risk of various cancers. However, its relationship to RCC remains unclear and no prospective data are available. Methods: We prospectively followed up 77,242 women in the Nurses’ Health Study and 30,071 men in the Health Professionals Follow-Up Study from 1996 to 2008. The information on the ABO blood group was collected from participants’ self-reports in 1996. Incidence of pathology-confirmed RCC was compared using hazard ratios (HRs) and 95% confidence intervals (CIs) derived from Cox proportional hazards models. Results: During 12 years of follow-up, 163 cases of incident RCC were documented in women and 88 cases in men. The multivariate HRs between non-O blood group (combined group of A, AB, and B) vs. blood group O were 1.51 (95% CI 1.09–2.09) in women, 1.08 (95% CI 0.70–1.66) in men, and 1.32 (95% CI 0.95–1.82) in the pooled cohorts. The associations between ABO blood group and RCC were consistent across strata of known risk factors for RCC including age, obesity, smoking, and history of hypertension (Pinteraction ≥ 0.32). Conclusions: We found a suggestive non-significant association between non-O blood group and increased risk of RCC in the pooled cohorts of men and women, and this association was significant in women. Our findings need to be replicated by other prospective studies. |
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