Rearranged abietane diterpenoid hydroquinones from aerial parts of Ajuga decumbens Thunb |
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Authors: | Bo Wang Xiao-Ning Wang Tao Shen Shu-Qi Wang Dong-Xiao Guo Hong-Xiang Lou |
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Affiliation: | Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, People''s Republic of China |
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Abstract: | Four new rearranged abietane diterpenoid hydroquinones, ajudecumins A–D (1–4), together with two known rearranged abietane diterpenoids, three neo-clerodane diterpenoids, four megastigmane derivatives, two flavonoids as well as a bisabolene sesquiterpenoid were isolated from the aerial parts of Ajuga decumbens. Their structures were established on the basis of extensive spectroscopic analysis and the stereochemistry of 1 was confirmed by single-crystal X-ray diffraction analysis. Among the diterpenoids, compounds 1 and 3 exhibited moderate inhibitory activity on the proliferation of human breast cancer MCF-7 cells. |
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