Naphthoquinones from the roots of Aloe secundiflora |
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| Authors: | Martha Induli Michael Cheloti Antonina Wasuna Ingrid Wekesa John M. Wanjohi Robert Byamukama Matthias Heydenrich Moses Makayoto Abiy Yenesew |
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| Affiliation: | 1. Department of Chemistry, University of Nairobi, P.O. Box 30197-00100, Nairobi, Kenya;2. Department of Chemistry, Makerere University, P.O. Box 7062, Kampala, Uganda;3. Kenya Industrial Research and Development Institute, P.O. Box 30650, Nairobi, Kenya;4. Institut f?r Chemie, Universität Potsdam, P.O. Box 60 15 53, D-14415 Potsdam, Germany |
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| Abstract: | Two new naphthoquinones, 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione and 5,8-dihydroxy-3-methoxy-2-methylnaphthalene-1,4-dione, were isolated from the roots of Aloe secundiflora together with the known compounds chrysophanol, helminthosporin, isoxanthorin, ancistroquinone C, aloesaponarins I and II, aloesaponols I and II, laccaic acid d methyl ester and asphodelin. The structures were elucidated based on spectroscopic evidence. This appears to be the first report on the occurrence of naphthoquinones in the genus Aloe. Aloesaponarin I and 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione showed anti-bacterial activity against Mycobacterium tuberculosis with MIC values of 21–23 μg/mL in the Microplate Alamar Blue Assay (MABA) and Low Oxygen Recovery Assay (LORA); 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione also showed cytotoxicity against the Vero cell line (IC50 = 10.2 μg/mL). |
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