New phenolics from the wood of Casearia grewiifolia

Two new phenolic compounds, threo-2,3-bis(4-hydroxy-3-methoxyphenyl)-3-butoxypropan-1-ol (1) and erythro-2,3-bis(4-hydroxy-3-methoxyphenyl)-3-butoxypropan-1-ol (2) were isolated from the wood of Casearia grewiifolia together with eight known compounds, N-trans-feruloyltyramine, ω-hydroxypropioguaiacone, C-veratroylglycol, syringaldehyde, vanillic acid, (?)-syringaresinol, β-sitosterol and β-sitosterone. The structures were elucidated by spectroscopic analysis, as well as comparison with literature data. This is the first study to identify the phenolic, amide, lignan and steroid constituents from C. grewiifolia and the new phenolics reported here are the first examples of 2,3-bis(4-hydroxy-3-methoxyphenyl)-1,3-propanoids found in the Caseria genus.