cis-Clerodane diterpenoids from the Chinese liverwort Scapania parva Steph. |
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| Authors: | Dong-Xiao Guo Xiao-Ning Wang Rong-Xiu Zhu Na Liu Jin-Chuan Zhou Wen-Tao Yu Hong-Xiang Lou |
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| Affiliation: | 1. Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, PR China;2. School of Chemistry and Chemical Engineering, Shandong University, No. 27 Shanda Nanlu, Jinan 250100, PR China;3. State Key Laboratory of Crystal Materials, Shandong University, No. 27 Shanda Nanlu, Jinan 250100, PR China |
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| Abstract: | Three undescribed cis-clerodane lactones, scapanialides A–C (1–3), and a new cis-clerodane furano-diterpenoid, scaparvin F (4), were isolated from the Chinese liverwort Scapania parva Steph. Scapanialide B (2) is the first cis-clerodane diterpenoid with a bicyclo[5.4.0]undecane skeleton from liverworts. Their structures including the absolute configurations were determined by extensive analysis of multidimensional NMR spectroscopy and TDDFT CD calculations, together with crystal X-ray diffraction measurements. The cytotoxicity of compounds 1–4 was preliminary tested against the Hela and MCF-7 cell lines. |
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