Sesquiterpenoids from the fruits of Alpinia oxyphylla and inhibition of nitric oxide production in lipopolysaccaride-activated macrophages |
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| Authors: | Jianguang Luo Xiaoqing Lv Xiaobing Wang Lingyi Kong |
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| Institution: | 1. State Key Laboratory of Natural Medicines, China Pharmaceutical University 24 Tong Jia Xiang, Nanjing 210009, People''s Republic of China;2. Department of Natural Medicinal Chemistry, China Pharmaceutical University 24 Tong Jia Xiang, Nanjing 210009, People''s Republic of China |
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| Abstract: | Three new norsesquiterpenoids, oxyphenol A (1), mandassion A (2) and mandassion B (3), along with three known compounds (4–6) were isolated from the fruits of Alpinia oxyphylla. Chemical structures of 1–3 were established by analysis of spectroscopic data. The absolute configuration of 2 and 3 was determined by the comparison of experimental electronic circular dichroism (ECD) spectroscopy and time-dependent density functional theory (TDDFT) calculations. Inhibitory effects of the six compounds on nitric oxide production in lipopolysaccaride-activated macrophages were evaluated, and compounds 3–5 showed significant inhibitory effect dependent on the concentration at the range of 1–50 μM. |
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