Diterpenoids from the root bark of Jatropha curcas and their cytotoxic activities |
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| Authors: | Xiao-Qiang Zhang Fu Li Zhi-Gang Zhao Xing-Li Liu Ya-Xiong Tang Ming-Kui Wang |
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| Institution: | 1. Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, People''s Republic of China;2. College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu 610041, People''s Republic of China;3. Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration and Biodiversity Conservation of Chinese Academy of Sciences, Key Laboratory of Sichuan Province, Chengdu 610041, People''s Republic of China |
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| Abstract: | Three new diterpenoids, named epi-jatrophol (1), jatrophaldehyde (2) and epi-jatrophaldehyde (3), along with nine known ones (4–12), were isolated from the root bark of Jatropha curcas. The new compounds were identified by spectroscopic data, and their relative configurations were confirmed by X-ray crystallography or chemical methods. The cytotoxic activities of the isolated compounds were evaluated against HEPG2 and LOVO tumor cell lines. Compounds 8, 9 and 10 were found to be cytotoxic toward HEPG2 cells for the first time. |
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