Glutathione S-transferase M1, T1, and P1 polymorphisms and thyroid cancer risk: A meta-analysis |
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| Authors: | Jianling Li Jianxiong Long Yanling Hu Aihua Tan Xuefeng Guo Shijun Zhang |
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| Affiliation: | 1. Institute of Cardiovascular Disease, First Affiliated Hospital of Guangxi Medical University, Nanning, China;2. School of Public Health, Guangxi Medical University, Nanning, China;3. Medical Research Center of Guangxi Medical University, Nanning, China;4. Cancer Hospital of Guangxi Medical University, Nanning, China;5. Department of Pharmacology, Guangxi Medical University, Nanning, China;1. Department of Radiation Oncology, Jean Minjoz University Teaching Hospital, Boulevard Flemming, Besançon F-25000, France;2. Department of Radiation Oncology, Centre Hospitalier Belfort-Montbéliard, Site du Mittan – 56 rue du Maréchal Juin – 25200 Montbéliard, France;3. Department of Pathology, Centre Hospitalier Belfort-Montbéliard, 25200 Montbéliard, France;4. Department of Head and Neck Surgery and Otology, Institut Universitaire de la Face et du Cou – Université Nice Sophia Antipolis, 33 av Valombrose, 06189 Nice, France;5. Department of Head and Neck Surgery, Aix-Marseille Univ – Centre Hospitalier universitaire La Timone, 264 rue Saint Pierre, 13005 Marseille, France;6. Department of Radiology, Centre Antoine Lacassagne – Institut Universitaire de la Face et du Cou – Université Nice Sophia Antipolis, 33 av Valombrose, 06189 Nice, France;7. Department of Pathology, Centre Hospitalier Universitaire – Institut Universitaire de la Face et du Cou – Université Nice Sophia Antipolis, 33 av Valombrose, 06189 Nice, France;8. Department of Pathology, CAL – Institut Universitaire de la Face et du Cou – Université Nice Sophia Antipolis, 33 av Valombrose, 06189 Nice, France;9. Department of Radiation Oncology, Centre Hospitalier Universitaire, 2 rue de la Milétrie, BP 577, 86021 Poitiers Cedex, France;10. Imaging Centre, 45 rue du Pont Rouge, 15000 Aurillac, France;11. Department of Medical Oncology, Jean Minjoz University Teaching Hospital, Boulevard Flemming, Besançon F-25000, France;12. Department of Head and Neck Surgery, Institut Universitaire de la Face et du Cou – Université Nice Sophia Antipolis, 33 av Valombrose, 06189 Nice, France;13. Department of Radiation Oncology, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, USA;14. Department of Radiation Oncology, Centre Antoine Lacassagne – Institut Universitaire de la Face et du Cou – Université Nice Sophia Antipolis, 33 av Valombrose, 06189 Nice, France;1. Division of Pathology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy;2. Endocrinology and Diabetology Unit, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy;3. Endocrine Unit, IRCCS Humanitas Research Hospital, University of Milan, Milan, Italy;4. Department of Biomedical, Surgical and Dental Sciences, University of Milan Medical School, Milan, Italy;1. Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University Hospital, Daejeon, Republic of Korea;2. Department of Otolaryngology-Head and Neck Surgery, Research Institute for Medical Science, Chungnam National University College of Medicine, Daejeon, Republic of Korea;3. Departments of Internal Medicine, Division of Endocrinology and Metabolism, Chungnam National University Hospital, Daejeon, Republic of Korea;4. Research Center for Endocrine and Metabolic Diseases, Chungnam National University College of Medicine, Daejeon, Republic of Korea;1. Servicio de Otorrinolaringología, Hospital Universitario de Salamanca, IBSAL (Instituto de Investigación Biomédica de Salamanca), Salamanca, España;2. Facultad de Medicina y Clínica Odontológica, Departamento de Cirugía, Universidad de Salamanca, Salamanca, España;3. Servicio de Pediatría, Complejo Asistencial de Zamora, Apoyo en Investigación en Epidemiología Clínica, Zamora, España;1. Department of Biology, University of Pisa, Italy;2. Department of Endocrinology, University of Pisa, Italy |
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| Abstract: | Glutathione S-transferases (GSTs) genetic variants have been explored extensively as a predictive factor for cancer etiology. This meta-analysis aimed to examine the associations GSTM1, GSTT1, and GSTP1 genetic polymorphisms with thyroid cancer risk. PubMed, EMBASE, Cochrane Library, and HuGNet database were searched up to November 2011 using the appropriate terms. Twelve studies regarding GSTM1 null polymorphism (1569 cases and 2907 controls), 11 studies concerning GSTT1 null polymorphism (1515 cases and 2863 controls), and 8 studies on GSTP1 Ile105Val (965 cases and 1604 controls) were included in the meta-analysis. The random effects odds ratio was 1.07 (95% CI: 0.88–1.31; I2 = 54.1%, P for heterogeneity = 0.013) for the GSTM1 null vs. present genotype and 1.08 (95% CI: 0.75–1.57; I2 = 81.4%, P for heterogeneity < 0.001) for the GSTT1 null vs. present genotype, and 1.02 (95% CI: 0.70–1.49; I2 = 74.6%, P for heterogeneity < 0.001) for the GSTP1 Val/Val + Val/Ile vs. Ile/Ile genotype. Similarly, no significant associations were demonstrated for subgroup analyses performed by ethnicity and histological type. In conclusion, these three polymorphisms are unlikely to be major determinants of susceptibility to thyroid cancer. Reasons for potential heterogeneity of effects, which could include true biologic heterogeneity, publication bias, or chance, deserve further investigation. The relationship between these three genes and thyroid carcinoma must be evaluated further with gene–gene and gene–environment interactions. |
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