Two new cytotoxic eudesmane sesquiterpenoids from Artemisia anomala |
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| Authors: | Ke Zan Xiao-Qing Chen Xing-Yun Chai Qing Wu Qiang Fu Si-Xiang Zhou Peng-Fei Tu |
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| Institution: | 1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China;2. School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China;3. Modern Research Center of Traditional Chinese Medicines, Beijing University of Chinese Medicine, Beijing 100029, China;4. Key Laboratory for Information System of Mountainous Area and Protection of Ecological Environment of Guizhou Province, Guizhou Normal University, Guiyang 550001, China |
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| Abstract: | Two new eudesmane sesquiterpenoids artanoate (1) and eudesmanomolide (2) were isolated from the aerial parts of Artemisia anomala S. Moore. Their structures were elucidated as methyl (4R, 5S, 6S, 7S, 10R)-1-oxo-4, 6-dihydroxy-eudesma-2, 11 (13)-dien-12-oate (1) and (1R, 5R, 6R, 10R)-3, 13-diacetoxy-1-hydroxy-3, 7(11)-diene-12, 6-olide (2) on the basis of extensive spectroscopic analyses. Compound 1 showed cytotoxicity against HCT-8 cell lines with IC50 value of 9.13 μM, and compound 2 exhibited inhibitory activities against HCT-8 and A549 cell lines with IC50 values of 3.76 and 5.49 μM, respectively. |
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