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Secondary metabolites from the liverwort Heteroscyphus coalitus
Authors:Zhao-Min Lin  Li-Ning Wang  Dong-Xiao Guo  Xiao-Ning Wang  Yong-Qing Liu  Jin-Chuan Zhou  Hong-Xiang Lou
Affiliation:Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, PR China
Abstract:A new dihydroisocoumarin derivative, R-(?)-heteroscyphide (1), together with three known terpenoid derivatives (24), were isolated from the liverwort Heteroscyphus coalitus. Their structures were elucidated by spectroscopic methods and the biogenetic pathway of compound 1 was proposed. Cytotoxic test revealed that they exhibited moderate inhibitory activity to three human tumor cell lines.
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