A functional polymorphism of lymphotoxin-alpha (LTA) gene rs909253 is associated with gastric cancer risk in an Asian population |
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| Authors: | Renquan Lu Xiaowei Dou Xiang Gao Jing Zhang Jian Ni Lin Guo |
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| Institution: | 1. Institute of Pharmacology and Clinical Pharmacy, Biochemical and Pharmacological Center (BPC) Marburg, University of Marburg, Karl-von-Frisch-Str. 1, D-35032 Marburg, Germany;2. Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Albertstr. 25, D-79104 Freiburg, Germany;3. BIOSS Centre for Biological Signalling Studies, University of Freiburg, Schänzlestr. 18, D-79104 Freiburg, Germany;1. Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland;2. Clinic for Internal Medicine C, University Greifswald, Greifswald, Germany;3. Department of Dermatology and Allergy, Skin Cancer Center, Charité—Universitätsmedizin Berlin, Berlin, Germany |
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| Abstract: | BackgroundThe potentially functional polymorphism, rs909253 (+252 G>A), in the intron region of the LT-α (TNF-β) gene has been implicated in the risk of gastric cancer (GC) in some individually published studies, but others have shown inconsistent and inconclusive results.MethodsWe conducted a meta-analysis to assess the association between the lymphotoxin-α gene (LTA) + 252 (G>A) polymorphism and gastric cancer susceptibility.ResultsWe demonstrate that there were no significant associations in single-locus analysis between the polymorphism of LTA and gastric cancer risk in all subjects; however, when studies were stratified by ethnicity, these polymorphisms of LTA were found to be associated with a significant cancer risk in different genetic models in an Asian population (heterozygote GA genotype] comparison: odds ratio OR] = 1.29, 95% confidence interval CI]: 1.01–1.65, P = 0.038) in which the risk in the subjects was more than 70% (12 studies with 2074 cases and 3690 controls). Moreover, the susceptibility to gastric carcinogenesis has a substantial influence on the population-attributable risk by modulating the effects of environmental risk factors such as Helicobacter pylori infection (OR = 1.77, 95%CI: 1.05–2.99, P = 0.032).ConclusionsThe present meta-analysis results suggest that the LTA rs909253 GA genotype is a possible risk factor for developing gastric cancer in the Asian population, especially those with H. pylori infection. |
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