Polygonflavanol A,a novel flavonostilbene glycoside from the roots of Polygonum multiflorum |
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| Authors: | Li-Li Chen Xiao-Jun Huang Man-Mei Li Guo-Min Ou Bing-Xin Zhao Min-Feng Chen Qing-Wen Zhang Ying Wang Wen-Cai Ye |
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| Institution: | 1. Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China;2. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, PR China;3. State Key Laboratory of Quality Research in Chinese Medicine (University of Macau) and Institute of Chinese Medical Sciences, University of Macau, Macao SAR, PR China |
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| Abstract: | Polygonflavanol A (1), a novel flavonostilbene glycoside with an unusual coupling pattern, together with five known stilbene glycosides (2–6), was isolated from the roots of Polygonum multiflorum. The structures were elucidated on the basis of extensive spectroscopic analysis and chemical evidence. The absolute configuration of 1 was further determined by CD analysis. Most of the compounds could inhibit nitric oxide (NO) secretion of RAW264.7 cells in respond to lipopolysaccharide (LPS) in a dose dependent manner. Among them, compound 2 displayed the highest inhibitory activity. |
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