Cytotoxic tetraoxygenated xanthones from the bark of Garcinia schomburgkiana |
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| Authors: | Hau T Vo Ngoc-Tuyet T Nguyen Hieu T Nguyen Khoa Q Do Joseph D Connolly Gerhard Maas Jörg Heilmann Udo R Werz Hung D Pham Lien-Hoa D Nguyen |
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| Institution: | 1. Natural Product and Medicinal Chemistry Lab, Faculty of Chemistry, Ho Chi Minh City University of Science, 227 Nguyen Van Cu, Ho Chi Minh City, Viet Nam;2. Institute of Organic Chemistry I, University of Ulm, Albert-Einstein-Allee 11, D-89081 Ulm, Germany;3. Department of Pharmaceutical Biology, University of Regensburg, Universitätsstraße 31, 93053 Regensburg, Germany;4. Department of Chemistry, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom |
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| Abstract: | Two new tetraoxygenated xanthones, 6-O-demethyloliverixanthone and schomburgxanthone, together with cowanin, cowanol, fuscaxanthones A and B, 3-isomangostin hydrate, and 1,7-dihydroxyxanthone, were isolated from the bark of Garcinia schomburgkiana. Their structures were elucidated using 1-D and 2-D NMR techniques as well as chemical methods. Five of the isolated compounds were tested regarding their cytotoxicity against HeLa cells and the results showed that fuscaxanthone B and cowanin possessed remarkable activity with IC50 values of 2.4 ± 0.2 and 2.7 ± 0.3 μg/ml, respectively, using an MTT assay. |
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