Toxic lanostane triterpenes from the basidiomycete Ganoderma amboinense |
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| Authors: | Sheng-Xiang Yang Zhao-Cheng Yu Qiang-Qiang Lu Wen-Quan Shi Hartmut Laatsch Jin-Ming Gao |
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| Institution: | 1. Shaanxi Engineering Center of Bioresource Chemistry & Sustainable Utilization, College of Sciences, Northwest A&F University, 3 Taicheng Road, Yangling 712100, Shaanxi, China;2. Department of Organic Chemistry, University of Goettingen, Tammannstrasse 2, D-37077 Goettingen, Germany;3. Edible Mushroom Division, Xi’an Institute of Agricultural Sciences, Xian, Shaanxi 710061, China |
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| Abstract: | A highly oxygenated new lanostane triterpene, designated as ganodermacetal (1), together with 15 related known compounds, has been isolated from the fruiting bodies of the basidiomycetous fungus Ganoderma amboinense. The structure of the new metabolite was elucidated on the basis of extensive spectroscopic analyses and chemical transformations. Ganodermacetal (1) possesses an uncommon 7,15-acetonide unit. Some of the isolated compounds showed significant toxic activity against brine shrimp larvae. |
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