neo-Clerodane diterpenes from Ajuga ciliata and their inhibitory activities on LPS-induced NO production |
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| Authors: | Ping Guo Yushan Li Da-qing Jin Jing Xu Yisha He Lei Zhang Yuanqiang Guo |
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| Institution: | 1. College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China;2. Department of Analytical Chemistry, College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China;3. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;4. School of Medicine, Nankai University, Tianjin 300071, China |
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| Abstract: | Two new neo-clerodane diterpenes, (12S)-6α-acetoxy-4α,18-epoxy-12-hydroxy-19-tigloyloxy-neo-clerod-13-en-15,16-olide (1) and 6α,18-diacetoxy-4α-hydroxy-19-tigloyloxy-neo-clerod-13-en-15,16-olide (2), along with three known analogs (3–5) have been isolated from the whole plants of Ajuga ciliata Bunge. Their structures were elucidated on the basis of spectroscopic data analyses (IR, ESI-MS, HR-ESI-MS, HMQC, HMBC, COSY, and NOESY). The inhibitory activities on LPS-induced NO production of these diterpenes were evaluated and compounds 1 and 5 showed inhibitory effects. |
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