Chemical constituents of Trilepisium madagascariense (Moraceae) and their antimicrobial activity |
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| Authors: | Patrick Y. Ango Deccaux W.F.G. Kapche Victor Kuete Bonaventure T. Ngadjui Merhatibeb Bezabih Berhanu M. Abegaz |
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| Affiliation: | 1. Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Cameroon;2. Department of Chemistry, Higher Teacher Training School, University of Yaoundé I, Cameroon;3. Department of Biochemistry, Faculty of Science, University of Dschang, Cameroon;4. Department of Chemistry, Faculty of Science, University of Botswana, Botswana |
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| Abstract: | The chemical study of Trilepisium madagascariense has led to the isolation of two previously undescribed compounds, (+)-(2S)-7-hydroxy-3′,4′-dimethoxyflavan (trilepisflavan) and (E)-4-[3-(3,4-dihydroxyphenyl)prop-2-enoyloxy]-3-hydroxybenzoic acid (trilepisuimic acid), together with ten known compounds caffeic acid, catechin, erythrodiol-3-O-palmitate, 8-C-glucopyranosylapigenin, dihydrokaempferol, protocatechuic acid, 3′,7-dihydroxy-4′-methoxyflavan, isoliquiritigenin, luteolin and 1,3-dimethoxybenzene. Their structures were elucidated on the basis of spectroscopic evidence. Crude extracts, trilepisflavan, dihydrokaempferol and 8-C-glucopyranosylapigenin showed significant antimicrobial activity. |
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