Effects of anticonvulsant agents and ethanol on the complexes of epileptic foci created by applications of bicuculline, strychnine, and penicillin in the rat brain cortex |
| |
Authors: | E A Fedorova D M Pykhteyev N V Ivanova G A Tokar |
| |
Institution: | (1) Bogatskii Physico-Chemical Institute, National Academy of Sciences of Ukraine, Kiev, Ukraine |
| |
Abstract: | Anticonvulsive effects of direct agonists of the GABA receptor system, medinal and phenazepam, as well as ethanol, on the
complexes of epileptic foci created in the rat brain cortex by applications of various convulsant agents (bicuculline, strychnine,
or penicillin) were studied. Ethanol, as well as phenazepam and medinal, were shown to possess high anti-epileptic activity
in relation to the complexes. It was shown, using an i.v. infusion technique, that threshold doses of strychnine and bicuculline
depend, in a linear and a nonlinear fashion, respectively, on the alcohol doses administered. A specific feature was found
in the pharmacolgoical effect of ethanol: anticonvulsive activity of ethanol was pronounced within the postinjection interval
from 5 min to 4 h, while within the following interval, from 4 to 24 h, the animals turned into a seizure-ready state. The
subseizure phase was observed under the conditions when the penicillin complex was induced, and also following i.v. injections
of strychnine and bicuculline. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|