Abnormal hemoglobins in the Silk Road region of China |
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| Authors: | Hou-jun Li Xian-ning Zhao Fan Qin Hui-wu Li Li Li Xiao-jun He Xiao-su Chang Zhe-meng Li Ke-xing Liang Fa-li Xing Wen-sun Chang Ru-zhau Wong Iu-li Yang Fen-sheng Li Tuen-tian Zhang Ri-jun Tian Brooke B. Webber Jerry B. Wilson Titus H. J. Huisman |
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| Affiliation: | (1) Laboratory of Medical Genetics, Western Region Hospital, Urumqi, People's Republic of China;(2) Hemoglobin Cooperative Study Group of the Lanzhou Military Area, Urumqi, People's Republic of China;(3) Laboratory of Protein Chemistry, Department of Cell and Molecular Biology, Medical College of Georgia, 30912-2100 Augusta, GA, USA |
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| Abstract: | Summary A review is presented of the occurrence of 24 abnormal hemoglobins (13  -chain variants and 11  -chain variants) in populations in the Silk Road area of Northwestern China. Most frequently occurring were Hb D-Punjab [21(GH4)Glu Gln] in Uygurs, Kazaks, and Khalkhas, Hb G-Taipei [22(B4)GluGly] in persons of the Han nationality, and Hb G-Coushatta [22 (B4)GluAla] in the Uygurs, Kazaks, Hans, and related nationalities. The data suggest that these variants likely originated in Central Asia, in the Han nationality of China, and in the minorities of northern China, respectively. Other variants occurred at considerably lower frequencies and were imported from other countries or arose as independent mutations. Two variants [Hb Tashikuergan or 19(AB1)AlaGlu; Hb Tianshui or 39(C5) GlnArg] were observed for the first time. The data from this study of the many variants support the movements of various populations in this area, as reported in numerous historical documents. |
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