Effects of beta-hydroxy butyric acid on insulin binding to its receptor and on autophosphorylation of the receptor |
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| Authors: | H Ohtsuka K Yamauchi N Ohara T Miyamoto K Ichikawa K Hashizume |
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| Affiliation: | Department of Geriatrics, Endocrinology and Metabolism, Shinshu University School of Medicine, Matsumoto, Japan. |
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| Abstract: | We examined the effects of beta-hydroxy butyric acid (B-OH-butyrate) on insulin binding to its receptor and on autophosphorylation of the receptor in vitro. The affinity of isolated rat adipocyte insulin receptors was significantly increased by B-OH-butyrate at neutral pH. Similar results were obtained with soluble insulin receptors prepared from hepatocytes. Autophosphorylation of insulin receptor, however, was not affected by OH-butyrate at neutral pH. These results suggested insulin resistance in ketoacidosis is not caused by an interaction between B-OH-butyrate and the insulin receptor. |
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