Analyzing marginal cases in differential shotgun proteomics |
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| Authors: | Carvalho Paulo C Fischer Juliana S G Perales Jonas Yates John R Barbosa Valmir C Bareinboim Elias |
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| Affiliation: | Center for Technological Development in Health, Oswaldo Cruz Institute, Rio de Janeiro, Brazil. paulo@pcarvalho.com |
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| Abstract: | SUMMARY: We present an approach to statistically pinpoint differentially expressed proteins that have quantitation values near the quantitation threshold and are not identified in all replicates (marginal cases). Our method uses a Bayesian strategy to combine parametric statistics with an empirical distribution built from the reproducibility quality of the technical replicates. AVAILABILITY: The software is freely available for academic use at http://pcarvalho.com/patternlab. |
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