Association between haptoglobin groups and hereditary predisposition for bronchial asthma |
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Authors: | N Fr?hlander N Stjernberg |
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Affiliation: | Department of Medical Genetics, University of Ume?, Sweden. |
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Abstract: | Haptoglobin (Hp) groups were investigated in 148 patients with bronchial asthma. A significant (p less than 0.005) deviation from the expected Hardy-Weinberg equilibrium, with a decreased frequency of heterozygotes, was observed among patients with a family history of asthma. This deviation was more pronounced among patients with adult onset of asthma. The presence or absence of atopy had no significant influence on the phenotype distribution. |
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