Pre- and postexposure prophylaxis of Ebola virus infection in an animal model by passive transfer of a neutralizing human antibody |
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| Authors: | Parren Paul W H I Geisbert Tom W Maruyama Toshiaki Jahrling Peter B Burton Dennis R |
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| Affiliation: | Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA. |
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| Abstract: | A neutralizing human monoclonal antibody, KZ52, protects guinea pigs from lethal Ebola Zaire virus challenge. Administration before or up to 1 h after challenge resulted in dose-dependent protection by the antibody. Interestingly, some antibody-treated animals survived despite developing high-level viremia, suggesting that the mechanism of protection by KZ52 may extend beyond reduction of viremia by virus neutralization. KZ52 is a promising candidate for immunoprophylaxis of Ebola virus infection. |
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