Cytotoxic labdane alkaloids from an ascidian Lissoclinum sp.: isolation, structure elucidation, and structure-activity relationship |
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Authors: | Uddin Jasim Ueda Katsuhiro Siwu Eric R O Kita Masaki Uemura Daisuke |
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Affiliation: | Department of Chemistry, Biology and Marine Sciences, University of the Ryukyus, Nishihara-cho, Okinawa 903-0213, Japan. |
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Abstract: | Four labdane alkaloids, haterumaimides N-Q (1-4), were isolated from an ascidian Lissoclinum sp. and their structures were elucidated by chemical and spectral analyses. Investigation of the structure-activity relationships of haterumaimides J-K, N-Q, and 14 related compounds suggested that the presence of hydroxyl groups at C-6, C-7, C-12, and C-18, a chlorine atom at C-2, and an imido NH in ring C should be essential for cytotoxicity against P388 cells. |
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