Hydrophobic tag-assisted liquid-phase synthesis of a growth hormone-inhibiting peptide somatostatin |
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| Authors: | Kitada Shingo Fujita Shuji Okada Yohei Kim Shokaku Chiba Kazuhiro |
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| Affiliation: | a Department of Applied Life Science, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan
b JITSUBO Co., Ltd, 2-24-16 Naka-cho, Koganei, Tokyo 184-0012, Japan |
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| Abstract: | Hydrophobic tag-assisted liquid-phase peptide synthesis technique and disulfide bond formation have been well-combined, leading to the efficient and practical preparation of a growth hormone-inhibiting peptide somatostatin. Intramolecular disulfide bond formation has successfully been carried out even under relatively high concentrations, enabling the effective peptide modifications in preparative scale. |
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| Keywords: | Hydrophobic tag Liquid-phase peptide synthesis Disulfide bond Cyclic peptide Somatostatin |
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