正常妇女不同卵巢激素状态离体输卵管平滑肌自发收缩活动及其对NE反应性研究

通过离体实验方法观察58例22—40岁中国育龄正常妇女周期的不同阶段、妊娠期(1—2个月)及哺乳期(2—10个月)输卵管峡部平滑肌收缩频率、波型及对外源性去甲肾上腺素(NE)的反应。实验观察到增生期、行经期及哺乳期峡部收缩活动比分泌期、妊娠期强,前者收缩频率高,多数呈现阵发性收缩,而后者收缩频率低,呈现单个收缩。增生期、行经期、分泌期及哺乳期峡部对NE呈兴奋性反应,只有妊娠期峡部对NE呈抑制反应。峡部环层肌比纵层肌收缩力强,但收缩波型相似。结果表明人输卵管自发收缩活动及对NE反应与卵巢激素状态有密切关系。

STUDIES ON THE SPONTANEOUS CONTRACTION AND THE RESPONSE TO NE OF ISOLATED OVIDUCTAL ISTHMIC MUSCLE FROM CHINESE WOMEN UNDER DIFFERENT OVARIAN HORMONAL STATES

Isolated isthmic smooth muscle of different phases (i.e. proliferative, secretory,menstrual, pregnant and lactating phase) from 58 normal Chinese women (22--40years old, during salpingectomy for sterilization) was used for the study of con-traction and sensitivity of response to norepinephrine (NE) (10~(-7)--10~(-3) mol/Laccumulative concentration). Isthmic smooth muscle activities at proliferative, menstrual and lactating phaseswere stronger and at a higher frequency than those at secretory and pregnant phases. The response of the isthmic smooth muscle to NE at proliferative, menstrual,secretory and lactating phases is excitatory in nature, while that at pregnant phaseis inhibitory. The result also shows that the contractility of circular muscleis stronger than that of longitudinal muscle but of similar contractile pattern.