Demonstration of a beta-casomorphin immunoreactive material in the plasma of newborn calves after milk intake |
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Authors: | Martin Umbach Hansjörg Teschemacher Karina Praetorius Richard Hirschhäuser Hartwig Bostedt |
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Affiliation: | 1. Rudolf Buchheim-Institut für Pharmakologie der Justus Liebig-Universität Gießen, D-6300 Gießen, F.R.G.;2. Ambulatorische und Geburtshilfliche Veterinärklinik der Justus Liebig-Universität Gießen, D-6300 Gießen, F.R.G. |
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Abstract: | Blood was collected from newborn calves before and after their first milk intake after birth; extracts of plasma were assayed by radioimmunoassay for the presence of beta-casomorphin-7 immunoreactive materials. No beta-casomorphin immunoreactivity was found in samples collected before milk ingestion; however, in samples collected after milk ingestion a beta-casomorphin-7 immunoreactive material was detected. Chromatographic characterization showed that this material was not identical with beta-casomorphin-7 but might rather represent a precursor thereof. The material proved resistant to enzymatic attack during a 30-min incubation period at 37 degrees C in the plasma of newborn calves, whereas beta-casomorphin-7 was degraded under these conditions. A physiological significance of beta-casomorphin-7 eventually cleaved from such a precursor material at any site in the newborn mammal is suggested. |
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Keywords: | β-casein opioid peptides neonatal physiology physiological significance of β-casomorphins |
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