Molecular archeology of L1 insertions in the human genome |
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| Authors: | Szak Suzanne T Pickeral Oxana K Makalowski Wojciech Boguski Mark S Landsman David Boeke Jef D |
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| Affiliation: | (1) National Center for Biotechnology Information (NCBI), National Library of Medicine, National Institutes of Health, 20894 Bethesda, MD, USA;(2) Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 725 N Wolfe St, 21205 Baltimore, MD, USA;(3) Biogen, Inc, 02142 Cambridge, MA, USA;(4) Human Genome Sciences, Inc, 20850 Rockville, MD, USA;(5) Department of Biology, The Pennsylvania State University, 0208 Mueller Lab, 16802 University Park, PA, USA;(6) Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, 98109 North Seattle, WA, USA; |
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| Abstract: | Background As the rough draft of the human genome sequence nears a finished product and other genome-sequencing projects accumulate sequence data exponentially, bioinformatics is emerging as an important tool for studies of transposon biology. In particular, L1 elements exhibit a variety of sequence structures after insertion into the human genome that are amenable to computational analysis. We carried out a detailed analysis of the anatomy and distribution of L1 elements in the human genome using a new computer program, TSDfinder, designed to identify transposon boundaries precisely. |
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