Calcium-activated neutral protease activities in brain trauma |
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Authors: | E. Arigoni F. Cohadon |
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Affiliation: | (1) Istituto di Farmacologia, Facoltà di Scienze, Università di Pavia, Italy;(2) Laboratoire de Neurochirurgie Expérimentale et Neurobiologie, Université de Bordeaux II, France |
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Abstract: | This paper investigates the level of cytosolic and synaptosomal forms of calcium activated neutral protease activities in the normal brain and their changes following a freezing lesion in the rabbit. From 1 to 24 hours post lesion we observe a progressive disappearing of the enzyme activities from the cytosolic compartment and concurrently their increase in the membranal fraction. These changes are likely to be due to a rise in intracellular calcium concentration, a well documented consequence of many cellular insults. The specific role of the activation of calpain activities in the pathophysiology of trauma is discussed, an enhancement of excitotoxic mechanisms is proposed. |
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Keywords: | Calpain CANP brain cryogenic insult |
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