Interactions of mercury in rat brain |
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| Authors: | I Falnoga I Kregar M Škreblin M Tušek-Žnidarič P Stegnar |
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| Institution: | 1. Institute Jo?ef Stefan, University of Ljubljana, 61111, Ljubljana, Slovenia
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| Abstract: | In order to study the metabolism of mercury (Hg), its affinity to metallothionein (MT), and its influence on levels of the
essential metals copper and zinc in the brain tissue of rats exposed to elemental mercury (HgO) vapor was investigated. The major findings were:
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After long-term exposure, about 40% of mercury was found in the brain water-soluble phase (supernatant);
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In brain supernatant, about 80% of Hg was found in the range of low-molecular-weight proteins; the MT-like protein Hg−Cu−Zn-thionein
was isolated and partially characterized;
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HgO vapor exposure resulted in increased tissue levels of essential Cu and Zn in addition to exogenous Hg; and
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Experiments showed that HgO vapor exposure can induce the stimulation of rat brain MT synthesis.
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A part of this investigation was reported at TEMA 7, Dubrovnik, May 20–25, 1990 (Falnoga et al 1991). |
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| Keywords: | Index Entries" target="_blank">Index Entries Mercury vapor mercury binding proteins metallothionein-like protein essential copper essential zinc rat brain |
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