Embryonic cortical neural stem cells migrate ventrally and persist as postnatal striatal stem cells |
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Authors: | Willaime-Morawek Sandrine Seaberg Raewyn M Batista Claudia Labbé Etienne Attisano Liliana Gorski Jessica A Jones Kevin R Kam Angela Morshead Cindi M van der Kooy Derek |
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Affiliation: | Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada. swmorawek@gmail.com |
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Abstract: | Embryonic cortical neural stem cells apparently have a transient existence, as they do not persist in the adult cortex. We sought to determine the fate of embryonic cortical stem cells by following Emx1(IREScre); LacZ/EGFP double-transgenic murine cells from midgestation into adulthood. Lineage tracing in combination with direct cell labeling and time-lapse video microscopy demonstrated that Emx1-lineage embryonic cortical stem cells migrate ventrally into the striatal germinal zone (GZ) perinatally and intermingle with striatal stem cells. Upon integration into the striatal GZ, cortical stem cells down-regulate Emx1 and up-regulate Dlx2, which is a homeobox gene characteristic of the developing striatum and striatal neural stem cells. This demonstrates the existence of a novel dorsal-to-ventral migration of neural stem cells in the perinatal forebrain. |
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