Synthetic studies of cis-4-Amino-L-proline derivatives as novel lipid lowering agents |
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| Authors: | Das Saibal Kumar Narasimha Rao Krovvidi V L Jagadheshan H Iqbal Javed |
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| Affiliation: | Discovery Chemistry, Dr. Reddy's Discovery Research, Bollaram Road, Miyapur, Hyderabad 500050, India. saibalkumardas@drreddys.com |
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| Abstract: | cis-4-Amino-L-proline derivatives 1 and 2 derived from quinazolinone and pyrazolo pyrimidone respectively were designed as novel lipid lowering agents. A preliminary in vivo screening indicates that 1b and 2a have moderate triglyceride lowering activity. |
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