The effect of anesthetics on hydrogen bonds An infrared study at low anesthetic concentrations |
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Authors: | René Buchet Camille Sandorfy |
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Institution: | Département de Chimie, Université de Montréal, Montréal, Québec H3C 3V1, Canada |
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Abstract: | It is shown that a striking parallelism exists between the anesthetic potency of general halocarbon anesthetics and their influence on the hydrogen bond association constants in N-H…OC type hydrogen bonds, important for shaping the ion channels. It is further shown that the effect of potent anesthetics (which contain an acidic hydrogen) on the free/associated ratio in such hydrogen bonds is still significant at clinical anesthetic concentrations. It is argued that the results are in keeping with a pluralistic theory of anesthesia based on both hydrophobic and polar interactions. |
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Keywords: | Hydrogen bonding Hydrophobic interaction Anesthetic Infrared spectroscopy N - Ethylacetamide |
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