Use of Cystatin C and Serum Creatinine for the Diagnosis of Contrast-Induced Nephropathy in Patients Undergoing Contrast-Enhanced Computed Tomography at an Oncology Centre |
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| Authors: | Joao Italo Fortalesa Melo Rubens Chojniak Debora Helena Costa Silva Jose Carlos Oliveira Junior Almir Galv?o Vieira Bitencourt Diego Holanda Silva Marcos Duarte Guimar?es Hernandes Cerqueira Souza Silva Denis Guilherme Teixeira Dias Winglison Carli Rodrigues Ellen Luzia Brancucci Barbara Martins Soares Cruz Beatriz Nunes Schiavon Juliana Luz Passos Argenton Margareth Arrivabene Camporini Adriana Zocchio |
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| Affiliation: | 1Department of Imaging - AC Camargo Cancer Center, São Paulo-SP, Brazil;2Department of Clinical Pathology - AC Camargo Cancer Center, São Paulo-SP, Brazil;3Statistical Nucleos - Campinas University School of Medicine, Campinas-SP, Brazil;UNIFESP Federal University of São Paulo, BRAZIL |
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| Abstract: | ObjectiveOur aim was to assess renal function using as laboratory measurements serum creatinine and cystatin C concentrations before and after administration of low-osmolarity (nonionic) iodinated contrast medium in patients with cancer undergoing computed tomography (CT).MethodsThis prospective study included 400 oncologic outpatients. Serum creatinine and cystatin C concentrations were measured before and 72 h after contrast administration. Glomerular filtration rates (GFRs) were estimated using serum creatinine–based [Modification of Diet in Renal Disease (MDRD) and Cockroft-Gault and cystatin C based (Larsson) equations. Exploratory data analysis was performed. The nonparametric Wilcoxon test was used to compare pre and post contrast of test results and estimated clearance. The confidence interval used in the analysis was 95%.ResultsCompared with the pre-contrast values, the mean serum creatinine concentration was significantly higher and average GFRs estimated using MDRD and Cockcroft-Gault equations were significantly lower after the administration of contrast (p <0.001). It was also observed a significant increase after contrast in the concentration of Cystatin C (p = 0.015). In addition, a decrease in GFR estimated using the average Larsson (p = 0.021) was observed between time points. However, none of the patients presented clinically significant nephropathy.ConclusionsAssessment using serum creatinine and cystatin C concentrations showed changes in renal function among patients with cancer undergoing contrast-enhanced CT examination in this study. No significant renal damage related to the use of low-osmolarity iodinated contrast medium of the type and dosage employed in this study was observed. This contrast medium is thus safe for use in patients with cancer. |
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