Human TM9SF4 Is a New Gene Down-Regulated by Hypoxia and Involved in Cell Adhesion of Leukemic Cells |
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| Authors: | Rosa Paolillo Isabella Spinello Maria Teresa Quaranta Luca Pasquini Elvira Pelosi Francesco Lo Coco Ugo Testa Catherine Labbaye |
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| Affiliation: | 1Department of Hematology, Oncology and Molecular Medicine of Istituto Superiore di Sanità, 00161, Rome, Italy;2Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, Rome, Italy;3Fondazione Santa Lucia, Rome, Italy;Emory University, UNITED STATES |
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| Abstract: | BackgroundThe transmembrane 9 superfamily protein member 4, TM9SF4, belongs to the TM9SF family of proteins highly conserved through evolution. TM9SF4 homologs, previously identified in many different species, were mainly involved in cellular adhesion, innate immunity and phagocytosis. In human, the function and biological significance of TM9SF4 are currently under investigation. However, TM9SF4 was found overexpressed in human metastatic melanoma and in a small subset of acute myeloid leukemia (AMLs) and myelodysplastic syndromes, consistent with an oncogenic function of this gene.ConclusionsAltogether, our study reports for the first time the expression of TM9SF4 at the level of normal and leukemic hematopoietic cells and its marked expression at the level of AMLs displaying granulocytic differentiation. |
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