covR Mediated Antibiofilm Activity of 3-Furancarboxaldehyde Increases the Virulence of Group A Streptococcus |
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| Authors: | Ganapathy Ashwinkumar Subramenium Dharmaprakash Viszwapriya Prasanth Mani Iyer Krishnaswamy Balamurugan Shunmugiah Karutha Pandian |
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| Institution: | Department of Biotechnology, Alagappa University, Science Campus, Karaikudi, Tamil Nadu, India;University of Oklahoma Health Sciences Center, UNITED STATES |
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| Abstract: | BackgroundGroup A streptococcus (GAS, Streptococcus pyogenes), a multi-virulent, exclusive human pathogen responsible for various invasive and non-invasive diseases possesses biofilm forming phenomenon as one of its pathogenic armaments. Recently, antibiofilm agents have gained prime importance, since inhibiting the biofilm formation is expected to reduce development of antibiotic resistance and increase their susceptibility to the host immune cells.SignificanceThough 3FCA possess antibiofilm activity against GAS, it was also found to increase the virulence of GAS. This study demonstrates that, covR mediated antibiofilm activity may increase the virulence of GAS. This also emphasizes the importance to analyse the acclimatization response and virulence of the pathogen in the presence of antibiofilm compounds prior to their clinical trials. |
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